Total Chemical Synthesis of Proteins
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Publisher: VCH ISBN: 9783527346608 Cover: HARDCOVER Date: 2021年03月 こちらの商品は学校・法人様向け(機関契約)のオンラインブック版がございます。 オンラインブックの価格、納期につきましては弊社営業員または当ECサイトよりお問い合わせください。 DESCRIPTION How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: * Contains valuable insights from the pioneers in the field of chemical protein synthesis * Presents proven synthetic approaches for a range of protein families * Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology. TABLE OF CONTENTS Characterization of synthetic proteins Native chemical ligation N to S acyl shifts in protein synthesis Hydrazide-based protein synthesis Chemical ubiquitination Glycoprotein synthesis Expediting protein synthesis Synthesis of membrane proteins Sugar-assisted ligation in protein synthesis Protein semisynthesis Expanding native chemical ligation via novel amino acid derivatives Oxime ligation Synthesis of selenoproteins Purification-free ligations Controlling segment solubility in large protein synthesis Total chemical synthesis of proteins in neurodegenerative diseases Solid phase chemical ligation Auxiliaries in chemical protein synthesis Peptide ligations at sterically demanding sites Protein synthesis applied for backbone protein engineering Histone synthesis Cylic peptide and protein synthesis via ligation methods Synthesis of proteins with post-translational modification mimics Deciphering protein folding using chemical protein synthesis
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