C-H Activation for Asymmetric Synthesis
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不斉合成のためのC-H活性化 Publisher: VCH ISBN: 9783527343409 Cover: HARDCOVER Date: 2019年09月 こちらの商品は学校・法人様向け(機関契約)のオンラインブック版がございます。 オンラインブックの価格、納期につきましては弊社営業員または当ECサイトよりお問い合わせください。 DESCRIPTION Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry. TABLE OF CONTENTS Part I Asymmetric Activation of C(sp3)-H Bonds 1 Part I.A C(sp3)-H Bond Insertion by Metal Carbenoids and Nitrenoids 2 1 Stereoselective C-C Bond-Forming Reactions Through C(sp3)-H Bond Insertion of Metal Carbenoids 3 2 Stereoselective C-N Bond-Forming Reactions Through C(sp3)-H Bond Insertion of Metal Nitrenoids 51 Part I.B C(sp3)-H Activation as Stereodiscriminant Step 77 3 Enantioselective Intra- and Intermolecular Couplings 79 4 Substrate-Controlled Transformation: Diastereoselective Functionalization 107 Part II Stereoselective Synthesis Implying Activation of C(sp2)-H Bonds 131 5 Planar Chirality via C(sp2)-H Activation Involved in Stereodiscriminant Step 133 6 Axial Chirality via C(sp2)-H Activation Involved in Stereodiscriminant Step 151 7 Central Chirality via Asymmetric C(sp2)-H Activation Implying Desymmetrization and Kinetic Resolution 175 8 Non-stereoselective C(sp2)-H Activation Followed by Selective Functionalization of Metallacyclic Intermediate 193 9 Diastereoselective Formation of Alkenes Through C(sp2)-H Bond Activation 239 Index 275
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