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Hormones
出版済み 3-5週間でお届けいたします。
Series: Advances in Protein Chemistry and Structural Biology Author: Donev, Rossen (ed.) Publisher: Elsevier USA ISBN: 9780443193460 Cover: HARDCOVER Date: 2024年07月 DESCRIPTION Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies - A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more. Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more. TABLE OF CONTENTS 1 Introduction 2 Overview of estrogen receptor 3 Role of estrogen receptor in glioblastoma 4 Therapeutic interventions-aromatase inhibitors potential 5 Nanoparticle-based delivery systems 6 Conclusion Acknowledgment References Chapter Two: Exploring the role of estrogen and progestins in breast cancer: A genomic approach to diagnosis Abstract 1 Introduction 2 Methods and materials 3 Identifying genes with differential expression 4 Functional enrichment analysis 5 Result and discussion 6 Differentially expressed genes-DESeq2 7 Functional enrichment analysis-g: Profiler 8 Conclusion Acknowledgments References Chapter Three: Diagnostic and predictive abilities of myokines in patients with heart failure Abstract Abbreviations 1 Heart failure: current challenges in prevalence and burden 2 Myokines: definition and general biological function 3 Myokines in adverse cardiac remodeling and heart failure 4 Conclusion References Chapter Four: Insight into vitamin D3 action within the ovary-Basic and clinical aspects Abstract Abbreviations 1 Vitamin D3 production and metabolism 2 Mechanism of vitamin D3 action 3 Physiology of the ovary and vitamin D3 4 Vitamin D3 deficiency and ovarian disorders 5 Vitamin D3 and OC Website Acknowledgments References Chapter Five: Hormonal basis of seasonal metabolic changes in mammalian species Abstract Abbreviations 1 Introduction 2 Photoperiod 3 Air temperature and seasonal changes in metabolism 4 Diet, vitamins and seasonal changes in metabolism 5 Atmospheric pressure and seasonal changes in metabolism 6 Seasonal changes in metabolism and season-dependent exacerbation of chronic disease 7 Conclusions References Chapter Six: Overlapping action of melatonin and female reproductive hormones-Understand the impact in pregnancy and menopause Graphical abstract Abstract 1 Introduction 2 Biosynthesis of melatonin and female reproductive hormones 3 Regulation of female reproductive hormones by melatonin 4 Melatonin in pregnancy and menopause: impact on clinical outcomes 5 Concluding remarks References Chapter Seven: Evolution of biosynthetic human insulin and its analogues for diabetes management Abstract 1 Introduction 2 The structural chemistry of insulin 3 Role of insulin in diabetes management 4 Conclusions References Chapter Eight: Hormonal regulation in diabetes: Special emphasis on sex hormones and metabolic traits Abstract 1 Introduction 2 Imbalance in sex hormones and its impact on diabetes 3 The impact of sex hormones on glucose metabolism in diabetes 4 Sex hormones and insulin: molecular pathway 5 Metabolic trait of diabetes: maternal or paternal 6 The clinical dilemma of diabetes among transgenders 7 Influence of metabolic traits on diabetic progression 8 The mechanism linking obesity and diabetes to oxidative stress and inflammation 9 The other way around: diabetes, a factor for reproductive disorders 10 Stress in modern life: a key factor for hormonal imbalance and diabetes 11 Diabetes management by hormonal therapy 12 Current research on sex hormones in diabetes 13 Future perspective 14 Conclusion Acknowledgments References Chapter Nine: Therapeutic potentials of glucose-dependent insulinotropic polypeptide (GIP) in T2DM: Past, present, and future Abstract 1 Introduction 2 Evolving patterns in incretin-based therapeutic approaches and medications 3 Past research on GIP in T2DM 4 Insulinotropic effects of GIP and GLP-1 5 Non-insulinotropic effects of GIP and GLP-1 6 Bifunctional role of GIP as a receptor activator and inhibitor 7 Role of GIP in lipidosis in white adipose tissue 8 Exploring the potential implications of GIP in other diseases 9 Cardiovascular disease 10 Non-alcoholic fatty liver disease 11 Neurodegenerative diseases 12 Renal diseases 13 GIPR: a promising therapeutic target for managing T2DM 14 Therapeutic potential of GIP in T2DM 15 Leveraging drug repurposing and target reutilization in T2DM management 16 Unlocking the potential of structurally modified GIP: a novel therapeutic avenue for T2DM 17 Overcoming the labyrinth: navigating obstacles in bringing incretin hormone-based therapies to the clinic 18 The future of GIP in T2DM 19 Conclusion References Chapter Ten: Thyroid hormone biosynthesis and its role in brain development and maintenance Abstract 1 Introduction 2 Historical perspective on thyroid hormone research 3 Thyroid gland anatomy 4 Steps in thyroid hormone biosynthesis 5 Deiodinases 6 Thyroid hormone receptors 7 Thyroid hormone transporters 8 Regulation of thyroid hormone biosynthesis 9 Effect of thyroid hormone on the brain 10 The hypothyroid brain 11 The hyperthyroid brain 12 Early neurogenesis and proliferation 13 Brain maintenance 14 Thyroid hormone and brain diseases 15 Impact of environmental disruptors on thyroid hormone-mediated neural function 16 Discussion Acknowledgments References Chapter Eleven: Biomarker identification of medullary thyroid carcinoma from gene expression profiles considering without-treatment and with-treatment studies-A bioinformatics approach Abstract Abbreviations 1 Introduction 2 Materials and methods 3 Results 4 Discussion 5 Conclusion Acknowledgments References Chapter Twelve: A crosstalk between ‘osteocyte lacunal-canalicular system’ and metabolism Abstract 1 Introduction 2 Materials and method for animal study 3 Structural and morphological analyses of femur bone 4 Statistical analysis of metabolic (serum) parameters 5 Strategy about the potential roles of metabolic relation 6 Limitation of current study 7 Conclusion 8 Funds Acknowledgment References Chapter Thirteen: Viral mimicry and endocrine system: Divulging the importance in host-microbial crosstalk Abstract 1 Introduction 2 Viral hormone mimics and their functions 3 Regulatory proteins and human hormones with homologous sequences in viral genomes 4 Viral molecular mimics implicated in cancer and autoimmune diseases 5 Concluding remarks References
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