Introduction to Heterocyclic Chemistry
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ヘテロ環化学入門 Author: Jacobi, Peter A. Publisher: Wiley ISBN: 9781119417590 Cover: PAPERBACK Date: 2018年10月 DESCRIPTION A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; pi-deficient heterocycles; pi-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. * Presents a conversational approach to a fundamental topic in organic chemistry teaching * Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles * Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses * Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology. TABLE OF CONTENTS 1 Some Biologically Important Heterocycles of Nature 1 2 Orbitals and Aromaticity; Chemical Reactivity 11 3 A Prelude to Synthesis 17 4 pi-Deficient Heterocycles: Some Physical Properties 23 5 pi-Deficient Heterocycles: De Novo Syntheses 27 6 pi-Deficient Heterocycles: Introduction of New Substituents: Nucleophilic Substitution 39 7 pi-Deficient Heterocycles: Introduction of New Substituents: Heterocyclic N-Oxides 49 8 pi-Deficient Heterocycles: Introduction of New Substituents: Quinolines and Isoquinolines 75 9 pi-Deficient Heterocycles: Manipulation of Existing Substituents 89 10 pi-Excessive Heterocycles: General Properties 107 11 pi-Excessive Heterocycles: De Novo Syntheses 115 12 pi-Excessive Heterocycles: Introduction of New Substituents 139 13 Ring Transformations of pi-Excessive Heterocycles: Diels-Alder Reactions 157 14 Heterocycles as Synthons 177 15 1,3-Dipolar Cycloadditions-An Overview 207 16 Back to Basics 239 17 A Brief Synopsis 247
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